Registered Nurses' Association of Ontario

Nursing Best Practice Guidelines

Common Renal Replacement Therapy Medication and their Effects in Pregnancy
Medication Potential Teratogenic Effect Gestational Risk Period
Angiotensin converting enzyme (ACE) inhibitors
  • fetal hypertension
  • anuria-oligohydramnios growth restriction pulmonary hypoplasia renal tubular dysphasia hypocalvaria
Second and third trimester
Cyclosporine Azathioprine Steroids
  • prematurity
  • hyaline membrane disease
  • hyperbilirubinemia
  • patient ductus arteriosus
  • transient hyponatremia
Throughout gestation period
Tacrolimus Immumosuppression

Mycophenolate mofetil Immunosuppression Steroids

  • prematurity



  • hypoplastic finger and toenails and shortened fifth fingers bilaterally
  • apnea and bradycardia with feeds aberrant blood vessel between trachea and esophagus
Throughout gestation period